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The breast cancer risk seen with combination hormone therapy in the Women's Health Initiative (WHI) trial persists in the long run, but estrogen alone may protect against it, according to long-term follow-up.
Over 13 years, the combination of estrogen and progestin (Prempro) was associated with a 28% increased risk of invasive breast cancer, comparable with the 24% greater risk seen in the original reporting of the trial, according to , of Brigham and Women's Hospital in Boston, and colleagues.
